名称:セマグルチド側鎖; セマグルチド活性エステル修飾剤; セマグルチド側鎖 NHS 活性化エステル
製品略称: tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu
CAS番号: 1118767-15-9
商品コード: 06040003000
保管: -20±5°C
セマグルチド側鎖（tBuO-Ste-Glu（AEEA-AEEA-OSu）-OtBu）は、ペプチド合成における側鎖の重要な保護基です。優れた溶解性と安定性を示し、化学反応中の非特異的な修飾や分解からアミノ酸側鎖を効果的に保護します。固相ペプチド合成とそれに続く官能基修飾に広く使用されているセマグルチド側鎖は、反応条件と選択性を制御し、副反応を最小限に抑えて製品の純度と収率を高めます。
I. アプリケーション
Drug Modification: tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is utilized in modifying small molecule drugs, proteins, antibodies, and other bioactive molecules. By forming stable amide bonds, it enhances drug solubility, stability, or targeting specificity, thereby improving therapeutic efficacy and safety. Particularly significant in the development of long-acting peptide drugs like Semaglutide, it plays a critical role in optimizing pharmacokinetic properties and therapeutic effects.
Targeted Drug Delivery: Leveraging its high reactivity and biocompatibility, tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is employed in constructing targeted drug delivery systems. This facilitates precise drug release within specific tissues or cells, enhancing therapeutic efficacy while reducing side effects.
Biological Probes and Diagnostic Reagents: As a component of biological probes or diagnostic reagents, this compound can detect specific molecules or cellular activities within organisms, providing robust support for disease diagnosis and treatment.
II. Production and Storage
Production: The production of tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu is typically carried out by specialized pharmaceutical intermediate manufacturers equipped with advanced synthesis technologies and stringent quality control systems.
Storage: It is recommended to store tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu at -20°C to ensure stability and activity.
III. Supplier Information
Currently, multiple suppliers, including but not limited to Xiamen Sinobestech Biotechnology Co., Ltd., offer tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu. These suppliers possess extensive production experience and rigorous quality control processes, ensuring high-quality products and excellent service for customers.
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| Name | Abbreviation | CAS# |
|---|---|---|
| Somarutopeptide carboxylic acid modifier | tBuO-Ste-Glu(AEEA-AEEA-OH)-OtBu | 1118767-16-0 |
| Somarutopeptide active ester modifier | tBuO-Ste-Glu(AEEA-AEEA-OSu)-OtBu | 1118767-15-9 |
| Somarutopeptide deprotection active ester modifier | HO-Ste-Glu(AEEA-AEEA-OSu)-OH | 1169630-40-3 |
| Somarutopeptide deprotection active ester modifier | HO-Ste-Glu(AEEA-AEEA-OSu)-OH(苄基路线) | 1169630-40-3 |
| Somarutopeptide side chain analogue 2 | tBuO-Ste-Glu(AEEEA-AEEEA-OH)-OtBu | / |
| Somarutopeptide side chain analogue 3 | tBuO-Ste-AEEEA-AEEEEEEA-OH | / |
| Somarutopeptide side chain analogue 4 | tBuO-Bz-Seb-Glu(AEEA-AEEA-OH)-OtBu | / |
| Somarutopeptide sodium salt modifier | tBuO-Ste-Glu(AEEA-AEEA-ONa)-OtBu | / |
| Somarutopeptide side chain analogue 6 | HO-Ste-Glu(AEEA-AEEA-Mal)-OH | / |
| Somarutopeptide side chain analogue 7 | HO-Ara-Glu(AEEA-AEEA-Mal)-OH | / |
| / | HO-Ara-Glu(NH-PEG6-NH-Mal)-OH | / |
| / | HO-Ara-NH-PEG9-NH-Mal | / |
| Somarutopeptide propionaldehyde modified side chain | tBuO-Ste-Glu(AEEA-AEEA-NH-pALD)-OtBu | / |
| Fmoc-Lys Somarutopeptide side chain | Fmoc-Lys(tBuO-Ste-Glu(AEEA-AEEA)-OtBu)-OH | 1662688-20-1 |
| Somarutopeptide side chain analogue 14 | Fmoc-Lys(tBuO-Pal-Glu(AEEA-AEEA)-OtBu)-OH | / |
| Somarutopeptide side chain analogue 15 | Fmoc-Lys(Pal-Glu(AEEA-AEEA)-OtBu)-OH | / |
| / | Fmoc-Lys(tBuO-Ara-Glu(AEEA)-OtBu)-OH | / |
